The basis
Why acoustic
Cell therapy and advanced bioprocessing demand a new generation of tools. Traditional methods (centrifugation, filtration, magnetic sorting) expose cells to mechanical stress, risking damage, unwanted activation, loss of viability (by 10–30%), contamination or variability between batches.
Aenitis’ acoustophoresis technology harnesses ultrasonic standing waves within a microfluidic channel to levitate and manipulate cells completely contact-free, without physical contact or mechanical stress. This allows cells to move between layers, enabling sorting, washing, isolation, or concentration in continuous flow.
The system operates through sterile connections and can be seamlessly integrated upstream or downstream of any flow-based setup.
How it powers Aenitis’ technology
Inside the Process
The Technology in Action
Our proprietary platform operates at the millifluidic scale, handling tens of milliliters per minute and per channel; an unmatched throughput for such a gentle method. By precisely controlling levitated cells with sound waves, we can perform operations such as:
- Cell washing – Remove unwanted media or reagents while keeping cells intact.
- Concentration – Reduce sample volume without stressing cells.
- Sorting and isolation – Select target cells without surface markers or harsh forces.
- Rare cell isolation – Recover valuable cells that would be lost with conventional methods.
Proven Benefits
Key benefits of this gentle, label-free, and pressure-free approach:
- Preserves native cell state, viability, and functionality (>90% across multiple cell types)
- Reduces processing time and operational costs
- Eliminates contamination risks
- Enables continuous, sterile, and reproducible workflows
- Requires no chemical labeling or tagging
Why it matters in biomanufacturing?
- Maximizes viable, functional cells, directly improving process yields
- Optimizes efficiency and reduces costs through gentler, streamlined workflows
- Enhances accessibility to biotherapies, supporting broader patient reach